B12 Deficiency: Homocysteine - “Vitamin B12 (mean 0.5 mg) produced an additional reduction in blood homocysteine of 7%, whereas vitamin B6 (mean 16.5 mg) did not have any significant effect. Hence, in typical populations, daily supplementation with both 0.5 to 5 mg folic acid and about 0.5 mg vitamin B12 would be expected to reduce homocysteine levels by one quarter to one third (from about 12 micromol/L to about 8 to 9 micromol/L).”
Pyridoxine (B6) nutritional status has a significant and selective modulatory impact on central production of both serotonin and GABA - neurotransmitters which control depression, pain perception, and anxiety.
Vitamin B6-dependent enzymes play a role in the biosynthesis of five neurotransmitters: serotonin, norepinephrine, epinephrine, dopamine and GABA. Vitamin B-6, comprised of pyridoxal, pyridoxamine, and pyridoxine, is one alternative treatment that may be a mitigating factor in hormone related depression, via its role in the proper metabolism of various neurotransmitters considered relevant in the manifestation of depression.